This text provides detailed coverage of physical methods used in bioinorganic chemistry. Individual chapters are devoted to electronic absorption spectroscopy, resonance Raman spectroscopy, electron paramagnetic resonance spectroscopy, ENDOR and ESEEM, magnetic circular dichroism, Mössbauer spectroscopy, magnetism, NMR spectroscopy as applied to paramagnetic systems, and x-ray absorption spectroscopy. The book aims to provide a fundamental understanding of each method and demonstrate how data obtained from a system of bioinorganic interest can be interpreted. Case studies are presented in the last chapter in which more than one technique has been applied to gain insight into each given bioinorganic problem. By integrating theory with experimentation and providing an orientation that is more biological than that presented in previously published books, Physical Methods in Bioinorganic Chemistry: Spectroscopy and Magnetism will serve as an important new text for students of bioinorganic chemistry, biochemistry, molecular biology, and their professors.
Modern spectroscopic and instrumental techniques are essential to the practice of inorganic and bioinorganic chemistry. This text provides a consistent and comprehensive description of the practical aaplicability of a large number of techniques to modern problems in organic and bioinorganic chemistry.
AN UPDATED, PRACTICAL GUIDE TO BIOINORGANIC CHEMISTRY Bioinorganic Chemistry: A Short Course, Second Edition provides the fundamentals of inorganic chemistry and biochemistry relevant to understanding bioinorganic topics. Rather than striving to provide a broad overview of the whole, rapidly expanding field, this resource provides essential background material, followed by detailed information on selected topics. The goal is to give readers the background, tools, and skills to research and study bioinorganic topics of special interest to them. This extensively updated premier reference and text: Presents review chapters on the essentials of inorganic chemistry and biochemistry Includes up-to-date information on instrumental and analytical techniques and computer-aided modeling and visualization programs Familiarizes readers with the primary literature sources and online resources Includes detailed coverage of Group 1 and 2 metal ions, concentrating on biological molecules that feature sodium, potassium, magnesium, and calcium ions Describes proteins and enzymes with iron-containing porphyrin ligand systems—myoglobin, hemoglobin, and the ubiquitous cytochrome metalloenzymes—and the non-heme, iron-containing proteins aconitase and methane monooxygenase Appropriate for one-semester bioinorganic chemistry courses for chemistry, biochemistry, and biology majors, this text is ideal for upper-level undergraduate and beginning graduate students. It is also a valuable reference for practitioners and researchers who need a general introduction to bioinorganic chemistry, as well as chemists who want an accessible desk reference.
Written by a preeminent teacher and scientist in the field, this book provides specialists, students, and general readers with an understanding of the basic chemistry of interactions of inorganic substances with biological systems at the molecular level. The author presents bioinorganic concepts in context and brings a distinct chemistry perspective to the subject. • Provides the streamlined coverage appropriate for one-semester courses or independent study, with all of the necessary but none of the excessive information • Prepares readers to move to the next level of study (whether they continue on in the field or transition to medicine/industry) • Presents concepts through extensive four-color visuals, appealing to a range of learning styles • Promotes critical thinking through open-ended questions throughout the narrative and at the end of each chapter
This volume on iron-sulfur proteins includes chapters that describe the initial discovery of iron-sulfur proteins in the 1960s to elucidation of the roles of iron sulfur clusters as prosthetic groups of enzymes, such as the citric acid cycle enzyme, aconitase, and numerous other proteins, ranging from nitrogenase to DNA repair proteins. The capacity of iron sulfur clusters to accept and delocalize single electrons is explained by basic chemical principles, which illustrate why iron sulfur proteins are uniquely suitable for electron transport and other activities. Techniques used for detection and stabilization of iron-sulfur clusters, including EPR and Mossbauer spectroscopies, are discussed because they are important for characterizing unrecognized and elusive iron sulfur proteins. Recent insights into how nitrogenase works have arisen from multiple advances, described here, including studies of high-resolution crystal structures. Numerous chapters discuss how microbes, plants, and animals synthesize these complex prosthetic groups, and why it is important to understand the chemistry and biogenesis of iron sulfur proteins. In addition to their vital importance in mitochondrial respiration, numerous iron sulfur proteins are important in maintenance of DNA integrity. Multiple rare human diseases with different clinical presentations are caused by mutations of genes in the iron sulfur cluster biogenesis pathway. Understanding iron sulfur proteins is important for understanding a rapidly expanding group of metabolic pathways important in all kingdoms of life, and for understanding processes ranging from nitrogen fixation to human disease.
This volume contains recent advances in spectrographic methods, including EPR, magnetic Mossbauer, paramagnetic and multi-D NMR, metalloprotein crystallography, EAS, magnetic circular dichroism, resonance Raman, X-ray absorption spectroscopy, and electron structure calculations. The book concentrates on topics where spectrographic methods have had a major impact, such as electron transfer, cluster interactions, intermediates, and definition of active site structure, and it includes a thorough tutorial on basic methods.
Over the past several decades there have been major advances in ourability to computationally evaluate the electronic structure ofinorganic molecules, particularly transition metal systems. Thisadvancement is due to the Moore’s Law increase in computingpower as well as the impact of density functional theory (DFT) andits implementation in commercial and freeware programs for quantumchemical calculations. Improved pure and hybrid density functionalsare allowing DFT calculations with accuracy comparable tohigh-level Hartree-Fock treatments, and the results of thesecalculations can now be evaluated by experiment. When calculations are correlated to, and supported by,experimental data they can provide fundamental insight intoelectronic structure and its contributions to physical propertiesand chemical reactivity. This interplay continues to expand andcontributes to both improved value of experimental results andimproved accuracy of computational predictions. The purpose of this EIC Book is to provide state-of-the-artpresentations of quantum mechanical and related methods and theirapplications, written by many of the leaders in the field. Part 1of this volume focuses on methods, their background andimplementation, and their use in describing bonding properties,energies, transition states and spectroscopic features. Part 2focuses on applications in bioinorganic chemistry and Part 3discusses inorganic chemistry, where electronic structurecalculations have already had a major impact. This addition to theEIC Book series is of significant value to both experimentalistsand theoreticians, and we anticipate that it will stimulate bothfurther development of the methodology and its applications in themany interdisciplinary fields that comprise modern inorganic andbioinorganic chemistry. This volume is also available as part of Encyclopedia ofInorganic Chemistry, 5 Volume Set. This set combines all volumes published as EIC Books from 2007to 2010, representing areas of key developments in the field ofinorganic chemistry published in the Encyclopedia of InorganicChemistry. ahref="http://eu.wiley.com/WileyCDA/WileyTitle/productCd-1119994284.html"Findout more/a.
Element speciation determines the different forms a chemical element can take within a given compound, enabling chemists to predict possible ramifications for the environment and human health. This comprehensive book focuses on the analytical aspects and instrumentation of speciation, while covering the gamut of metal speciation forms with adverse effects on biological materials and the environment at large. The book consists of contributions by a truly international group of leading authorities on element speciation in bioinorganic chemistry. The editor—a contributor here himself—traces the developments in the field, discussing the advances made over the past decade in various methodologies and the significance of the increased capacity to detect extremely small concentrations of trace elements in various media. Several chapters are dedicated to the various methods and applications of speciation, exploring specific analytical methods, such as direct, chromatographic and nonchromatographic methods, as well as nuclear-based and voltammetric methods. Others cover speciation in various natural water and marine environments and its manifestation in biological materials, human serum, or foodstuff. In addition, the book examines speciation theory and legal aspects as well as questions of quality and sources of errors—issues that underscore the perennial need to develop new methods for obtaining still more accurate data. Extremely broad in scope and rich in detail, this volume provides the key to improving the state of the art in the field, and is sure to stimulate further research. It stands as a one-of-a-kind reference for analytical and inorganic chemists, as well as biochemists, in a wide range of disciplines, including toxicology, environmental science, nutrition research, clinical chemistry, and pharmacology. A complete reference for the analytical and instrumental aspects of speciation This unique volume provides both a comprehensive reference and a practical guide to the complete range of issues arising from element speciation. It concentrates on analytical methods and instrumentation in bioinorganic chemistry—especially as applied to water-related projects—while addressing the larger environmental and human-health concerns of our times. Complete with over 100 illustrations, this collaborative effort by an international group of experts describes Methods for the detection and analysis of species elements, including direct methods, atomic spectrometry, nuclear activation analysis and radio tracer, high-performance chromatography, or voltammetric procedures Specific effects of various species elements, including heavy metals, arsenic, and many other trace elements Biological materials showing concentrations of trace elements, including human serum, milk, and marine organisms Various environments affected by element speciation, such as natural waters, sea waters, estuarine, and coastal environments How to avoid common pitfalls and obtain sound and accurate data For anyone involved in environmental and earth sciences, as well as the related areas of public health, pharmacology, toxicology, nutritional research, or environmental regulations, this important work offers the most systematic survey of element speciation to date. It also provides historical perspective, a preview of expected developments, and a multitude of new ideas for further research. The author of approximately 240 published papers and three previous books, Dr. Caroli is an active member of numerous national and international committees and organizations concerned with chemicals in the environment. He also sits on the editorial or advisory boards of several scientific journals, including the Journal of Analytical Atomic Spectroscopy, Environmental Science and Pollution Research International, and Microchemical Journal.
This book consists of over 300 problems (and their solutions) in structural inorganic chemistry at the senior undergraduate and beginning graduate level. The topics covered comprise Atomic and Molecular Electronic States, Atomic Orbitals, Hybrid Orbitals, Molecular Symmetry, Molecular Geometry and Bonding, Crystal Field Theory, Molecular Orbital Theory, Vibrational Spectroscopy, and Crystal Structure. The central theme running through these topics is symmetry, molecular or crystalline. The problems collected in this volume originate in examination papers and take-home assignments that have been part of the teaching of the book's two senior authors' at The Chinese University of Hong Kong over the past four decades. The authors' courses include Chemical Bonding, Elementary Quantum Chemistry, Advanced Inorganic Chemistry, X-Ray Crystallography, etc. The problems have been tested by generations of students taking these courses.