The sixth edition of this successful book encourages good prescribing habits in doctors throughout the world, by describing the basic properties of antibiotics and other antimicrobial agents, and discussing the principles underlying the rational use of antimicrobial agents in the management of infection.
The fifth edition of this successful book encourages good prescribing habits in doctors throughout the world, by describing the basic properties of antibiotics and other antimicrobial agents, and discussing the principles underlying the rational use of antimicrobial agents in the management of infection.
One of a series of pocketbooks designed to provide easily assimilable information on common medical issues. The concise texts are enhanced by tables and diagrams summarizing the essential information. This volume deals with antimicrobial therapy.
Biomedical scientists are the foundation of modern healthcare, from cancer screening to diagnosing HIV, from blood transfusion for surgery to food poisoning and infection control. Without biomedical scientists, the diagnosis of disease, the evaluation of the effectiveness of treatment, andresearch into the causes and cures of disease would not be possible.The Fundamentals of Biomedical Science series has been written to reflect the challenges of practicing biomedical science today. It draws together essential basic science with insights into laboratory practice to show how an understanding of the biology of disease is coupled to the analyticalapproaches that lead to diagnosis. Assuming only a minimum of prior knowledge, the series reviews the full range of disciplines to which a Biomedical Scientist may be exposed - from microbiology to cytopathology to transfusion science.The series:- Understands the complex roles of Biomedical Scientists in the modern practice of medicine.- Understands the development needs of employers and the Profession.- Addresses the need for understanding of a range of fundamental sciences in the context of Biomedicine.- Places the theoretical aspects of Biomedical Science in their practical context via clinical case studies.Medical Microbiology covers a range of key laboratory techniques used in the diagnosis of important human diseases caused by microorganisms. From sample collection, through to analysis and laboratory investigation, the text covers a wide range of procedures and highlights how and why results aregenerated. The third edition has been expanded to cover a wider range of topics, including a new chapter on Whole Genome Sequencing and extended coverage of syphilis and MALDI.
This volume surveys some of the most recent developments in antimicrobial chemotherapy and emphasises our increasing knowledge of how these compounds exert their effects. It is 18 years since the Society for General Microbiology published a symposium volume devoted specifically to antimicrobial agents. Since then many new compounds have been described and marketed and enormous strides have been made in our understanding of the mode of action of antimicrobial compounds. This volume reflects these advances in the areas of cell wall active antibiotics, inhibitors of bacterial protein synthesis, antibacterial quinolones, antiprotozoal, antifungal and antiviral agents, antibiotic resistance, drug design and production, novel in vitro methods, and ways of supporting chemotherapeutic attack. Although antimicrobial agents are used for many purposes outside human therapy - and the book is sufficiently general to be of interest to workers in these other fields - the emphasis is on agents and issues that impinge on the clinical use of these drugs, so as to maintain a pragmatic perspective for the flights of high science that so easily tend otherwise to leave practical considerations behind.
Part of the Oxford Infectious Disease Library, this pocketbook is designed to help medical trainees, general prescribers, healthcare workers and students to understand how antibiotics work, to demonstrate where they might be most appropriate, and to make clear the threat of antibiotic resistance.
The concept of chemotherapy as originated by Paul Ehrlich is based on the premise that antiparasitic drugs must have two properties: they must first bind to specific structures of the parasite which Ehrlich called chemoreceptors. Subsequent to their attachment to the chemoreceptor and by virtue of this binding they must possess the capacity to kill the parasite. Since the host which is to be cured of an invading parasite also contains a large number of chemoreceptors, that have the potential to bind toxic compounds, the task of the chemo therapist is to identify chemoreceptors of the parasite which are . not represented in the host and to design drugs which bind selectively to them~ In this context, Ehrlich called· for "the complete and exhaustive knowledge of all the different chemoreceptors of a certain parasite" as a "sine qua non for success in chemotherapy". Paradoxically and in spite of the fact that chemotherapy has become a very advanced and successful therapeutic discipline, few of its tri umphs have been achieved by following Ehrlich's original precepts. On the contrary, in the overwhelming majority of cases, effective drugs have been discovered without any knowledge of their chemoreceptors, and these drugs themselves have conversely been used as tools to study the nature of the chemoreceptors involved. In other words: chemother apy, notably antibacterial chemotherapy, has been successful without ever living up to the fundamental standards put forward by Paul Ehr lich.
The management of sepsis has an essential role in surgical care and surgeons are major users of antimicrobial agents. Indeed, the development of antimicrobial drugs has enabled the development of modern surgery, free of the morbidity and mortality associated with septic complications. To use antimicrobial agents effectively, the surgeon needs an understanding of the microbiological and pharmacological basis of their role as well as their clinical use. This book is a manual of good practice giving essential advice on the choice of agent for the full range of surgical infections - taking both optimal clinical use and cost-effectiveness into account. The book provides a succinct and up-to-date account of those antimicrobial agents (including antiviral agents) more commonly used in surgery. It is structured both to review antimicrobial agent by type and by their mode of use in various surgical subspecialties. Extensive cross-referencing, tabulation and a good index ensure that the optimal treatment regimen for any given clinical situation can be found quickly. There is also an extensive bibliography. Antimicrobial resistance - an ever increasing problem worldwide - is highlighted and there are major sections on the use of antifungal agents and antibiotic use in immunocompromized patients. The book is designed as a guide to good practice for trainee surgeons and will also be useful to postgraduate and professional surgeons in all subspecialties faced with difficult surgical infection.