Medical

Complex Systems Science in Biomedicine

Author: Thomas Deisboeck

Publisher: Springer Science & Business Media

ISBN:

Category: Medical

Page: 864

View: 295

Complex Systems Science in Biomedicine Thomas S. Deisboeck and J. Yasha Kresh Complex Systems Science in Biomedicine covers the emerging field of systems science involving the application of physics, mathematics, engineering and computational methods and techniques to the study of biomedicine including nonlinear dynamics at the molecular, cellular, multi-cellular tissue, and organismic level. With all chapters helmed by leading scientists in the field, Complex Systems Science in Biomedicine's goal is to offer its audience a timely compendium of the ongoing research directed to the understanding of biological processes as whole systems instead of as isolated component parts. In Parts I & II, Complex Systems Science in Biomedicine provides a general systems thinking perspective and presents some of the fundamental theoretical underpinnings of this rapidly emerging field. Part III then follows with a multi-scaled approach, spanning from the molecular to macroscopic level, exemplified by studying such diverse areas as molecular networks and developmental processes, the immune and nervous systems, the heart, cancer and multi-organ failure. The volume concludes with Part IV that addresses methods and techniques driven in design and development by this new understanding of biomedical science. Key Topics Include: • Historic Perspectives of General Systems Thinking • Fundamental Methods and Techniques for Studying Complex Dynamical Systems • Applications from Molecular Networks to Disease Processes • Enabling Technologies for Exploration of Systems in the Life Sciences Complex Systems Science in Biomedicine is essential reading for experimental, theoretical, and interdisciplinary scientists working in the biomedical research field interested in a comprehensive overview of this rapidly emerging field. About the Editors: Thomas S. Deisboeck is currently Assistant Professor of Radiology at Massachusetts General Hospital and Harvard Medical School in Boston. An expert in interdisciplinary cancer modeling, Dr. Deisboeck is Director of the Complex Biosystems Modeling Laboratory which is part of the Harvard-MIT Martinos Center for Biomedical Imaging. J. Yasha Kresh is currently Professor of Cardiothoracic Surgery and Research Director, Professor of Medicine and Director of Cardiovascular Biophysics at the Drexel University College of Medicine. An expert in dynamical systems, he holds appointments in the School of Biomedical Engineering and Health Systems, Dept. of Mechanical Engineering and Molecular Pathobiology Program. Prof. Kresh is Fellow of the American College of Cardiology, American Heart Association, Biomedical Engineering Society, American Institute for Medical and Biological Engineering.
Medical

Complex Systems Science in Biomedicine

Author: Thomas Deisboeck

Publisher: Springer

ISBN:

Category: Medical

Page: 864

View: 141

Complex Systems Science in Biomedicine Thomas S. Deisboeck and J. Yasha Kresh Complex Systems Science in Biomedicine covers the emerging field of systems science involving the application of physics, mathematics, engineering and computational methods and techniques to the study of biomedicine including nonlinear dynamics at the molecular, cellular, multi-cellular tissue, and organismic level. With all chapters helmed by leading scientists in the field, Complex Systems Science in Biomedicine's goal is to offer its audience a timely compendium of the ongoing research directed to the understanding of biological processes as whole systems instead of as isolated component parts. In Parts I & II, Complex Systems Science in Biomedicine provides a general systems thinking perspective and presents some of the fundamental theoretical underpinnings of this rapidly emerging field. Part III then follows with a multi-scaled approach, spanning from the molecular to macroscopic level, exemplified by studying such diverse areas as molecular networks and developmental processes, the immune and nervous systems, the heart, cancer and multi-organ failure. The volume concludes with Part IV that addresses methods and techniques driven in design and development by this new understanding of biomedical science. Key Topics Include: • Historic Perspectives of General Systems Thinking • Fundamental Methods and Techniques for Studying Complex Dynamical Systems • Applications from Molecular Networks to Disease Processes • Enabling Technologies for Exploration of Systems in the Life Sciences Complex Systems Science in Biomedicine is essential reading for experimental, theoretical, and interdisciplinary scientists working in the biomedical research field interested in a comprehensive overview of this rapidly emerging field. About the Editors: Thomas S. Deisboeck is currently Assistant Professor of Radiology at Massachusetts General Hospital and Harvard Medical School in Boston. An expert in interdisciplinary cancer modeling, Dr. Deisboeck is Director of the Complex Biosystems Modeling Laboratory which is part of the Harvard-MIT Martinos Center for Biomedical Imaging. J. Yasha Kresh is currently Professor of Cardiothoracic Surgery and Research Director, Professor of Medicine and Director of Cardiovascular Biophysics at the Drexel University College of Medicine. An expert in dynamical systems, he holds appointments in the School of Biomedical Engineering and Health Systems, Dept. of Mechanical Engineering and Molecular Pathobiology Program. Prof. Kresh is Fellow of the American College of Cardiology, American Heart Association, Biomedical Engineering Society, American Institute for Medical and Biological Engineering.
Medical

Complex Systems Science in Biomedicine

Author: Thomas S. Deisboeck

Publisher: Kluwer Academic Publishers

ISBN:

Category: Medical

Page:

View: 205

Complex Systems Science in Biomedicine will address the fundamentals of complex systems science, its applicability and relevance to biological and medical grand challenges and its potential for the development of novel research tools as well as innovative diagnostic and treatment strategies. This textbook focuses on the importance of complex systems science in biomedical research and its impact on clinical problem solving. In Parts I and II, the book describes general topics in complex systems science with implications for biomedicine so that the interested, non-specialist, is able to understand the underlying hypothesis as well as the approaches and techniques used in the following sections. The core of the book (Part III) features the application of the aforementioned techniques to specific biomedical topics, starting with the molecular and cellular levels, to whole organ systems (such as the brain and the immune system), leading to the description of dynamical disease processes such as cancer and aging. These examples have been chosen because of their importance and impact for the future (e.g., cancer, HIV, aging). The last part of the book (Part IV) discusses emergent technolog
Technology & Engineering

The Local Information Dynamics of Distributed Computation in Complex Systems

Author: Joseph T. Lizier

Publisher: Springer Science & Business Media

ISBN:

Category: Technology & Engineering

Page: 236

View: 843

The nature of distributed computation in complex systems has often been described in terms of memory, communication and processing. This thesis presents a complete information-theoretic framework to quantify these operations on information (i.e. information storage, transfer and modification), and in particular their dynamics in space and time. The framework is applied to cellular automata, and delivers important insights into the fundamental nature of distributed computation and the dynamics of complex systems (e.g. that gliders are dominant information transfer agents). Applications to several important network models, including random Boolean networks, suggest that the capability for information storage and coherent transfer are maximised near the critical regime in certain order-chaos phase transitions. Further applications to study and design information structure in the contexts of computational neuroscience and guided self-organisation underline the practical utility of the techniques presented here.
Science

Complex Systems in Biomedicine

Author: A. Quarteroni

Publisher: Springer Science & Business Media

ISBN:

Category: Science

Page: 292

View: 813

Mathematicalmodelingofhumanphysiopathologyisatremendouslyambitioustask. It encompasses the modeling of most diverse compartments such as the cardiovas- lar,respiratory,skeletalandnervoussystems,aswellasthemechanicalandbioch- ical interaction between blood ?ow and arterial walls, and electrocardiac processes and electric conduction in biological tissues. Mathematical models can be set up to simulate both vasculogenesis (the aggregation and organization of endothelial cells dispersed in a given environment) and angiogenesis (the formation of new vessels sprouting from an existing vessel) that are relevant to the formation of vascular networks, and in particular to the description of tumor growth. The integration of models aimed at simulating the cooperation and interrelation of different systems is an even more dif?cult task. It calls for the setting up of, for instance, interaction models for the integrated cardio-vascular system and the interplay between the central circulation and peripheral compartments, models for the mid-to-long range cardiovascular adjustments to pathological conditions (e.g., to account for surgical interventions, congenital malformations, or tumor growth), models for integration among circulation, tissue perfusion, biochemical and thermal regulation, models for parameter identi?cation and sensitivity analysis to parameter changes or data uncertainty – and many others.
Science

Encyclopedia of Complexity and Systems Science

Author:

Publisher: Springer

ISBN:

Category: Science

Page: 10398

View: 412

This encyclopedia provides an authoritative single source for understanding and applying the concepts of complexity theory together with the tools and measures for analyzing complex systems in all fields of science and engineering. It links fundamental concepts of mathematics and computational sciences to applications in the physical sciences, engineering, biomedicine, economics and the social sciences.
Science

Encyclopedia of Complexity and Systems Science

Author:

Publisher: Springer

ISBN:

Category: Science

Page: 10398

View: 688

This encyclopedia provides an authoritative single source for understanding and applying the concepts of complexity theory together with the tools and measures for analyzing complex systems in all fields of science and engineering. It links fundamental concepts of mathematics and computational sciences to applications in the physical sciences, engineering, biomedicine, economics and the social sciences.
Science

Encyclopedia of Complexity and Systems Science

Author:

Publisher: Springer

ISBN:

Category: Science

Page: 10398

View: 660

This encyclopedia provides an authoritative single source for understanding and applying the concepts of complexity theory together with the tools and measures for analyzing complex systems in all fields of science and engineering. It links fundamental concepts of mathematics and computational sciences to applications in the physical sciences, engineering, biomedicine, economics and the social sciences.
Science

Encyclopedia of Complexity and Systems Science

Author:

Publisher: Springer

ISBN:

Category: Science

Page: 10398

View: 868

This encyclopedia provides an authoritative single source for understanding and applying the concepts of complexity theory together with the tools and measures for analyzing complex systems in all fields of science and engineering. It links fundamental concepts of mathematics and computational sciences to applications in the physical sciences, engineering, biomedicine, economics and the social sciences.
Science

Encyclopedia of Complexity and Systems Science

Author:

Publisher: Springer

ISBN:

Category: Science

Page: 10398

View: 228

This encyclopedia provides an authoritative single source for understanding and applying the concepts of complexity theory together with the tools and measures for analyzing complex systems in all fields of science and engineering. It links fundamental concepts of mathematics and computational sciences to applications in the physical sciences, engineering, biomedicine, economics and the social sciences.
Science

Encyclopedia of Complexity and Systems Science

Author:

Publisher: Springer

ISBN:

Category: Science

Page: 10398

View: 774

This encyclopedia provides an authoritative single source for understanding and applying the concepts of complexity theory together with the tools and measures for analyzing complex systems in all fields of science and engineering. It links fundamental concepts of mathematics and computational sciences to applications in the physical sciences, engineering, biomedicine, economics and the social sciences.
Science

Encyclopedia of Complexity and Systems Science

Author:

Publisher: Springer

ISBN:

Category: Science

Page: 10398

View: 719

This encyclopedia provides an authoritative single source for understanding and applying the concepts of complexity theory together with the tools and measures for analyzing complex systems in all fields of science and engineering. It links fundamental concepts of mathematics and computational sciences to applications in the physical sciences, engineering, biomedicine, economics and the social sciences.
Science

Encyclopedia of Complexity and Systems Science

Author:

Publisher: Springer

ISBN:

Category: Science

Page: 10398

View: 915

This encyclopedia provides an authoritative single source for understanding and applying the concepts of complexity theory together with the tools and measures for analyzing complex systems in all fields of science and engineering. It links fundamental concepts of mathematics and computational sciences to applications in the physical sciences, engineering, biomedicine, economics and the social sciences.
Information technology

The Standards Edge

Author: Sherrie Bolin

Publisher:

ISBN:

Category: Information technology

Page: 233

View: 519

Looks at open source and open standards from a business viewpoint. Emphasis on strategies that can help to both maximize open source and overcome its challenges as it applies to user, vendors, and government policy makers.
Science

Encyclopedia of Complexity and Systems Science

Author:

Publisher: Springer

ISBN:

Category: Science

Page: 10398

View: 389

This encyclopedia provides an authoritative single source for understanding and applying the concepts of complexity theory together with the tools and measures for analyzing complex systems in all fields of science and engineering. It links fundamental concepts of mathematics and computational sciences to applications in the physical sciences, engineering, biomedicine, economics and the social sciences.
Science

Open Systems Science

Author: Mario Tokoro

Publisher: IOS Press

ISBN:

Category: Science

Page: 262

View: 893

Open systems science is the methodology employed to manage and solve the problems in systems whose operation involves interaction with the outside world, as opposed to being closed and complete within themselves. This new methodology was first announced at the 20th anniversary symposium of Sony CSL in 2008. Falling outside the direct scope of traditional science, an open system usually consists of multiple subsystems with varying numbers, relations and functions. Throughout the last decades, computer scientists, addressing the problems presented by globalization and the massive expansion in the application of new technologies, began to realize that open systems science could provide some of the solutions they were seeking with regard to complex and dependable systems. Starting with a chapter explaining the basic concept of open systems science, this book goes on to present the work of contributors from a variety of different disciplines, who explain how open systems science can be applied to their field. Including topics such as; biological robustness, the application of open systems methods to develop new drugs, the study of language and meaning, the interdisciplinary field of visual computing and user interfaces as the merger between the real and virtual world, this book explores the directions of science and technology in the 21st century and will be of interest to all those involved in the development and operation of complex interactive systems. IOS Press is an international science, technical and medical publisher of high-quality books for academics, scientists, and professionals in all fields. Some of the areas we publish in: -Biomedicine -Oncology -Artificial intelligence -Databases and information systems -Maritime engineering -Nanotechnology -Geoengineering -All aspects of physics -E-governance -E-commerce -The knowledge economy -Urban studies -Arms control -Understanding and responding to terrorism -Medical informatics -Computer Sciences