A genome is an organism's complete set of DNA, including all of its genes. Each genome contains all of the information needed to build and maintain that organism. In humans, a copy of the entire genome-more than three billion DNA base pairs-is contained in all cells that have a nucleus. Developmental Genetics studies how the genes regulate developmental changes in behavior and influence scientific approaches in several fields. It highlights the interdisciplinary approach of developmental genetics with new revolutionary technologies and details how these advances have accelerated our understanding of the molecular genetic processes that regulates development. Chromosomes come in matching sets of two (or pairs) and there are hundreds-sometimes thousands-of genes in just one chromosome. The chromosomes and genes are made of DNA, which is short for deoxyribonucleic. Genes, Genomes, and Genomics, with chapters written by internationally renowned experts, provide an enormous reservoir of new information in the various theoretical and applied aspects of unravelling the secrets hidden in the genes of plants, animals and microorganisms. A gene is the basic physical and functional unit of heredity. Genes, which are made up of DNA, act as instructions to make molecules called proteins. In humans, genes vary in size from a few hundred DNA bases to more than two million bases. Moreover, the book presents a thorough overview of a wide array of methodologies from classical genetics to modern genomics technologies.
Did you know that most of our bodies' cells contain about 6 feet (2 meters) of DNA? Learn how DNA and genes determine each unique trait of plants and animals by taking a close look at the make up and structure of DNA.
Discover the mystery of science with Future Geniuses! Little Doctor Valentina is back with a brand new adventure! This time, join Valentina as she explains the concept of genetics, using her adorable puppy, Mendel, as her model. With her handy microscope, Valentina examines Mendel’s cells and teaches us all about cell parts—organelles, membranes, cytoplasm, and finally, the powerhouse of the cell, the nucleus. Within the nucleus, Valentina points out the DNA and the genes that explain everything about us—like why Mendel is yellow and his siblings are brown! Dive deep into the world of genetics and learn all about nitrogen bases, RNA, chromosomes, mitosis, and more. Uncover what makes you, well, you! Future Geniuses is a collection that will help families spend a lot of time reading and learning together. Through simple text and fun illustrations, author and scientist Carlos Pazos makes the subject of genetics approachable and easy to understand for even the smallest scientists.
This book takes the reader deep inside a cell to see where genes are found and goes behind the headlines to explain cloning, gene therapy, the human genome, DNA testing, GM foods, genetic engineering, and much more.
Explains the role of DNA and genes in reproduction, and discusses heredity, the history of genetics, such new techniques and developments as genetic engineering and cloning, and the ethical issues which they may raise.
Recombinant DNA, Third Edition, is an essential text for undergraduate, graduate, and professional courses in Genomics, Cell and Molecular Biology, Recombinant DNA, Genetic Engineering, Human Genetics, Biotechnology, and Bioinformatics. The Third Edition of this landmark text offers an authoritative, accessible, and engaging introduction to modern, genome-centered biology from its foremost practitioners. The new edition explores core concepts in molecular biology in a contemporary inquiry-based context, building its coverage around the most relevant and exciting examples of current research and landmark experiments that redefined our understanding of DNA. As a result, students learn how working scientists make real high-impact discoveries. The first chapters provide an introduction to the fundamental concepts of genetics and genomics, an inside look at the Human Genome Project, bioinformatic and experimental techniques for large-scale genomic studies, and a survey of epigenetics and RNA interference. The final chapters cover the quest to identify disease-causing genes, the genetic basis of cancer, and DNA fingerprinting and forensics. In these chapters the authors provide examples of practical applications in human medicine, and discuss the future of human genetics and genomics projects.
Cells obey the laws of physics and chemistry; DNA as a store of information; Genes are metable units; DNA is the genetic material; The topology of nucleic acids; Isolating the gene; Turning genes into proteins; The assembly line for protein sysnthesis; Transfer RNA: the translational adaptor; The ribosome translation factory; The messenger RNA templlate; Controlling gene expression by transcription; RNA polymerase-promoter interactions control initiation; A panoply of operons: the lactose paradigm and others; Control at termination: attenuation and antitermination; Lytic cascades and lysogenic repression; Perpetuation of DNA; The replicon: unit of replication; The apparatus for DNA replication; Systems that safeguard DNA; Constitution of the eukaryotic genome; The extraordinary power of DNA technology; A continuum of sequences includes structural genes; The organization of interrupted genes; Clusters of relates sequences; Structural genes belond to families of various sizes; Genomes sequestered in organelles; Organization of simple sequence DNA; Reachiong maturity: RNA processing; Cutting and trimming stable RNA; RNNA as catalyst: mechanisms of splicing; Control of RNA processing; The packaging of DNA; About genomes and chromosomes; Chromatin structure: the nucleosome; The nature of active chromatin; The dynamic genome: DNA in flux; Recombination and other topological manipulations of DNA; Transposable elements in bacteria; Mobile elements in eukaryotes; Enginnering changes in the genome; Genes in development; Rearrangements and the generation of immune diversity; Changing gene organization from within and without; Gene regulation: changing patterns of expression; Oncogenes: aberrant gene expression and cancer; Landmark changes in perspectives.
This edition focuses on the core concepts of human and molecular genetics. Chapters have been re-ordered to make the book more logical and basic definitions easy to find. There is an increased emphasis on genomics, reflected both in new material and the reorganisation of the contents.
“... an excellent book... achieves all of its goals with style, clarity and completeness... You can see the power and possibilities of molecular genetics as you read...” –Human Genetics "This volume hits an outstanding balance among readability, coverage, and detail." –Biochemistry and Molecular Biology Education Rapid advances in a collection of techniques referred to as gene technology, genetic engineering, recombinant DNA technology and gene cloning have pushed molecular biology to the forefront of the biological sciences. This new edition of a concise, well-written textbook introduces key techniques and concepts involved in cloning genes and in studying their expression and variation. The book opens with a brief review of the basic concepts of molecular biology, before moving on to describe the key molecular methods and how they fit together. This ranges from the cloning and study of individual genes to the sequencing of whole genomes, and the analysis of genome-wide information. Finally, the book moves on to consider some of the applications of these techniques, in biotechnology, medicine and agriculture, as well as in research that is causing the current explosion of knowledge across the biological sciences. From Genes to Genomes: Concepts and Applications of DNA Technology, Second Edition includes full two-colour design throughout. Specific changes for the new edition include: Strengthening of gene to genome theme Updating and reinforcing of material on proteomics, gene therapy and stem cells More eukaryotic/mammalian examples and less focus on bacteria This textbook is must-have for all undergraduates studying intermediate molecular genetics within the biological and biomedical sciences. It is also of interest for researchers and all those needing to update their knowledge of this rapidly moving field.
This timely book was written to provide students and the general reader with basic knowledge relating to DNA, genes, and genetic engineering. The great mass of technical data has been condensed to the essentials and presented in a simple and understandable summary form. Numerous practical applications are highlighted throughout the book and the comprehensive glossary will be an especially helpful feature. Readers with only a smattering of chemistry and biology should have no difficulty understanding the ideas or following the procedures outlined in this exceptional new resource.
The principles of cloning DNA; Recombination and mutagenesis of DNA in vitro; Bacteriophage vectors; Bacterial plasmid vectors; Expression of cloned DNAs in E. coli plasmids; The physical characterization of cloned DNA segments and their counterparts within chromosomes; Gene cloning in fungi and plants; Expression of cloned genes in animal cells.
In accordance with its predecessor, the completely revised andexpanded Second Edition of Modern Microbial Genetics focuseson how bacteria and bacteriophage arrange and rearrange theirgenetic material through mutation, evolution, and genetic exchangeto take optimal advantage of their environment. The text is divided into three sections: DNA Metabolism, GeneticResponse, and Genetic Exchange. The first addresses how DNAreplicates, repairs itself, and recombines, as well as how it maybe manipulated. The second section is devoted to how microorganismsinteract with their environment, including chapters on sporulationand stress shock, and the final section contains the latestinformation on classic exchange mechanisms such as transformationand conjugation. Chapters include: Gene Expression and Its Regulation Single-Stranded DNA Phages Genetic Tools for Dissecting Motility and Development ofMyxococcus xanthus Molecular Mechanism of Quorum Sensing Transduction in Gram-Negative Bacteria Genetic Approaches in Bacteria with No Natural GeneticSystems The editors also cultivate an attention to global regulatorysystems throughout the book, elucidating how certain genes andoperons in bacteria, defined as regulons, network and cooperate tosuit the needs of the bacterial cell. With clear appreciation forthe impact of molecular genomics, this completely revised andupdated edition proves that Modern Microbial Geneticsremains the benchmark text in its field.