Through this book, we can see that the synthesis of steroids continuous to be a challenge for many teams of research. Indeed, due to the molecular biology, the bio-chemistry of steroids is going to be better understand. The steroids receptors are going to be better explored. the biological activities of those oxo steroids for which data are available have been given. we note that most of the efforts till now were concentrated on the synthesis of steroids containing a new ring fused to a ring A, ring D are bridging ring A and B
IgA nephropathy is the most common primary glomerulonephritis in developed countries. The primary defect lies in the abnormalities of the IgA molecule. The disease affects all ages, mainly in the young adults, and may recur in a transplanted kidney. This outstanding volume provides a comprehensive overview of the advances in this disease over the last ten years. It covers the genetics, epidemiology, clinicopathological features, pathogenesis, prognostic mechanisms, and treatment of this unique disease. Twenty-seven chapters are written by 43 experts from 13 countries; these experts have been providing forefront scientific findings to the scientific community for the last 20 years. The book covers all clinical, pathological and molecular aspects of IgA nephropathy. This is an essential source of reference for nephrologists, internists, pathologists, and molecular biologists. It is also suitable reading for graduate students or research scientists in the field of kidney diseases.
The long-term use of glucocorticoids is associated with several deleterious effects. Attempts to separate the beneficial from the adverse effects of these compounds have met with varying degrees of difficulty. The discovery of distinct modes of action of the glucocorticoid receptor, the protein that mediates glucocorticoid action has opened up many possibilities for improving glucocorticoid therapy. This book provides an in-depth overview of the molecular actions of the glucocorticoid receptor and discusses the chances of an imminent identification of selective glucocorticoid agonists. Such componds should fulfill all the criteria of a glucocorticoid but should lack the sideeffects so far linked with classical glucocorticoids.