Medical

A Comprehensive Text Book on Self-emulsifying Drug Delivery Systems

Author: Deepak Kaushik

Publisher: Bentham Science Publishers

ISBN:

Category: Medical

Page: 211

View: 957

This text book is a guide for pharmaceutical academics (students and teachers) as well as industry professionals learning about drug delivery and formulation. Chapters presents comprehensive information about self-emulsifying formulations by providing an in-depth understanding of the basic concepts and formulation mechanisms. This information is supplemented by details about current research and development in this field. Readers will learn about the types of self-emulsifying drug delivery systems, evaluation parameters and digestion models, among other topics. Key Features: - 9 chapters organized in a reader-friendly layout - complete guide on self-emulsifying drug delivery formulations, including lipid based systems, SMEDOs, surfactants, and oral dosage forms - includes basic concepts and current developments in research and industrial applications - presents information on conventional and herbal formulations - references for further reading

Self-Emulsifying Drug Delivery Systems

Author: Himani Bajaj

Publisher: LAP Lambert Academic Publishing

ISBN:

Category:

Page: 64

View: 560

The book entitled self emulsifying drug delivery systems contains need, importance, factors affecting, advantages, disaadvantages, formulation tools, techniques and dosage forms of this delivery systems.It laid emphasis on the barriers in absorption of poorly water soluble drug and techniques to overcome these barriers.The applications of this systems in various forms have been discussed.The main objective of this systems is bioavailabilty enhancemen

Solid Self Emulsifying Drug Delivery System of Glibenclamide

Author: Maria Saifee

Publisher: LAP Lambert Academic Publishing

ISBN:

Category:

Page: 120

View: 590

The study was aimed to develop solid self micro emulsifying drug delivery system (S-SEDDS) for dissolution enhancement of model drug Glibenclamide using Aerosil 200 as solid carrier. SEDDS was prepared using oil, surfactant and cosurfactant respectively. Pseudo ternary phase diagram was used to identify micro emulsion region for formulating stable SEEDS .Prepared SEDDS was evaluated for turbidity measurement, globule size and zeta potential, viscosity determination and % transmittance. S-SEDDS was prepared by adsorption technique using Aerosil 200 as solid carrier. Prepared S-SEDDS was evaluated for flow properties, drug content, FTIR, SEM, DSC and in-vitro dissolution study. Results showed that prepared liquid SEDDS passed all evaluation tests. S-SEDDS showed good flow property and drug content. From the experiment, it is clear that even after conversion of the liquid SEDDS into the solid SEEDS, their is no significant alteration in its propertites.Thus Solid SEEDS can be used as a means of dissolution enhancement technique.

Self Emulsifying Drug Delivery System

Author: Naisarg Pujara

Publisher: LAP Lambert Academic Publishing

ISBN:

Category:

Page: 84

View: 933

Oral drug delivery systems being the most cost-effective and leads the worldwide drug delivery market. The major problem in oral drug system is low and erratic bioavailability, which mainly results from poor aqueous solubility. This may lead to high inter and intra subject variability, lack of dose proportionality and therapeutic failure. For the improvement of bio-availability of drugs with such properties presents one of the greatest challenges in drug formulations. Various technological strategies are reported in the literature including solid dispersions, cyclodextrines complex formation and micronization. Including these approaches self-emulsifying drug delivery system (SEDDS) has gained more attention for enhancement of oral bio-availability with reduction in dose. SEDDS are isotropic mixtures of oil, surfactants, solvents and co-solvents/surfactants. For lipophilic drugs, which have dissolution rate-limited absorption, SEDDS may be a promising strategy to improve the rate and extent of oral absorption. This book explains how self-emulsifying drug delivery systems can increase the solubility and bioavailability of poorly soluble drug.

Development of Self Microemulsifying Drug Delivery System

Author: Priyank B. Patel

Publisher: LAP Lambert Academic Publishing

ISBN:

Category:

Page: 108

View: 784

Nearly 40% of new drug candidates exhibit low solubility in water, which leads to poor oral bioavailability, high intra- and inter-subject variability and lack of dose proportionality. Modification of the physicochemical properties, such as salt formation and particle size reduction of the compound may be one approach to improve the dissolution rate. . In recent years, much attention has focused on lipid based formulations to improve the oral bioavailability of poorly water soluble drug compounds. In fact, the most popular approach is the incorporation of the drug compound into inert lipid vehicles such as oils, surfactant dispersions, self-emulsifying formulations, emulsions and liposomes with particular emphasis on self microemulsifying drug delivery systems (SMEDDS).
Medical

Pharmaceutical Drug Delivery Systems and Vehicles

Author: Suryakanta Swain

Publisher: CRC Press

ISBN:

Category: Medical

Page: 369

View: 219

Pharmaceutical Drug Delivery Systems and Vehicles focuses on the fundamental principles while touching upon the advances in the pharma field with coverage of the basic concepts, fundamental principles, biomedical rationales, preparative and characterization techniques, and potential applications of pharmaceutical drug delivery systems and vehicles.

A Comprehensive Text Book on Self-emulsifying Drug Delivery Systems

Author: Ravinder Verma

Publisher: Bentham Science Publishers

ISBN:

Category:

Page: 212

View: 900

This text book is a guide for pharmaceutical academics (students and teachers) as well as industry professionals learning about drug delivery and formulation. Chapters presents comprehensive information about self-emulsifying formulations by providing an in-depth understanding of the basic concepts and formulation mechanisms. This information is supplemented by details about current research and development in this field. Readers will learn about the types of self-emulsifying drug delivery systems, evaluation parameters and digestion models, among other topics. Key Features: - 9 chapters organized in a reader-friendly layout - complete guide on self-emulsifying drug delivery formulations, including lipid based systems, SMEDOs, surfactants, and oral dosage forms - includes basic concepts and current developments in research and industrial applications - presents information on conventional and herbal formulations - references for further readin

Self Microemulsifying Drug Delivery System For Some Drugs

Author: Vikrant Wankhade

Publisher: LAP Lambert Academic Publishing

ISBN:

Category:

Page: 280

View: 761

BCS class II are poorly water soluble and some drugs have high molecular weight, more than eleven hydrogen bond acceptors, more than five hydrogen bond doner. Thus, it exhibits poor bioavailability. A new Solid-Self Emulsifying Drug Delivery System (S-SMEDDS) of Drugs has been successfully developed to enhance its oral bioavailability by improving its solubility and facilitating high molecular weight of Drugs absorption. The primary composition of SMEDDS formulation was selected from solubility, pseudoternary phase diagram, emulsifying efficiency and compatibility test for preparation of (L-SMEDDS). Drug loaded L-SMEDDS were prepared in different concentration of oil, surfactant/co-surfactant and optimized by various evolutionary parameter such as robustness to dilution, drug content, ultrasonic interferometer, ease of emulsification, droplet size and in vitro diffusion study. The optimized L-SMEDDS converted into free flowing granules by spray drying technique. S-SMEDDS powder undergoes for characterization and confirmed the no interaction between drug and excipients.Thus, the present investigation improved the oral bioavailability of Drugs.
Drug delivery systems

Development of Self Microemulsifying Drug Delivery System

Author: Maulik Patel

Publisher: LAP Lambert Academic Publishing

ISBN:

Category: Drug delivery systems

Page: 104

View: 999

Nearly 40% of new drug candidates exhibit low solubility in water, which leads to poor oral bioavailability, high intra- and inter-subject variability and lack of dose proportionality. Modification of the physicochemical properties, such as salt formation and particle size reduction of the compound may be one approach to improve the dissolution rate of the drug. However, these methods have their own limitations. In recent years, much attention has focused on lipid based formulations to improve the oral bioavailability of poorly water soluble drugs. In fact, the most popular approach is the incorporation of the drug compound into inert lipid vehicles such as oils, surfactant dispersions, self-emulsifying formulations, emulsions and liposomes with particular emphasis on self-microemulsifying drug delivery systems (SMEDDS).

Self-Emulsifying Systems for Oral Bioavailability Enhancement of Drugs

Author: Suryakanta Swain

Publisher: LAP Lambert Academic Publishing

ISBN:

Category:

Page: 84

View: 546

Self-nanoemulsifying drug delivery systems (SNEDDS) have been proved as technologically worthwhile, effortlessly scalable and economically sound delivery systems for enhancing the oral bioavailability of highly lipophilic drugs. Distinct merits of smaller globule size, higher solubilization tendency and robust formulation advantages have made them as one of the most promising alternatives among the diverse lipid-based nanostructured systems. In the last two decades, the phenomenal success of SNEDDS as a potential delivery platform for oral delivery of drugs has gained phenomenal interest in academia and industry with utility of them in non-oral drug delivery too. The current book manuscript provides an overview account on the recent advances in the development of self-nanoemulsifying formulations along with their characterization and applications in enhancing biopharmaceutical performance of the drugs. Besides, the book highlights two research case studies as instances to the pharmaceutical formulation scientists for development of solid self-nanoemulsifying systems of two poorly water soluble drugs, ondansetron and valsartan, for enhancing their oral bioavailability.
Medical

Oral Lipid-Based Formulations

Author: David J. Hauss

Publisher: CRC Press

ISBN:

Category: Medical

Page: 368

View: 464

Oral lipid-based formulations are attracting considerable attention due to their capacity to facilitate gastrointestinal absorption and reduce or eliminate the effect of food on the absorption of poorly water-soluble, lipophilic drugs. Despite the obvious and demonstrated utility of these formulations for addressing a persistent and growing problem of major significance, the pharmaceutical industry has been slow to apply and further develop this technology. This title provides a comprehensive summary of the theoretical and practical aspects of oral lipid-based formulations for use in industry, and provides further insights into a developing technology expected to assume increasing prominence in years to come.